Next‐generation ERM system: ‘ERM Essentials’ in context

ERM proteins

compensate for one another, although there is no evidence of true biochemical redundancy. The genomes of lower organisms, such as Caenorhabditis elegans, Drosophila melanogaster and Danio rerio, harbor single ERM orthologues; in fact, ERMs appeared evolutionarily during the transition to multicellularity and an ERM-like protein is encoded by the genome of the choanoflagellate Monosiga brevicoli...

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.

ERM (ezrin-radixin-moesin) proteins mediate linkage of actin cytoskeleton to plasma membrane in many cells. ERM activity is regulated in part by phosphorylation at a C-terminal threonine, but the identity of ERM kinases is unknown in lymphocytes and incompletely defined in other mammalian cells. Our studies show that lymphocyte-oriented kinase (LOK) is an ERM kinase in vitro and in vivo. Mass s...

ERM proteins in cancer progression.

Members of the ezrin-radixin-moesin (ERM) family of proteins are involved in multiple aspects of cell migration by acting both as crosslinkers between the membrane, receptors and the actin cytoskeleton, and as regulators of signalling molecules that are implicated in cell adhesion, cell polarity and migration. Increasing evidence suggests that the regulation of cell signalling and the cytoskele...

ERM immersion vaccination and adjuvants

ERM Scheme for Quantile Regression

and Applied Analysis 3 Under the same assumptions asTheorem 4, we get that by replacing ι by n/s, for any 0 < δ < 1, with confidence 1 − δ, 󵄩󵄩󵄩󵄩 fz − fτ,ρ 󵄩󵄩󵄩󵄩Lr ρX ≤ ?̃?m −θ log 2 δ , (13)